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Journal article

Characterization of novel promoter and enhancer elements of the mouse homologue of the Dent disease gene, CLCN5, implicated in X-linked hereditary nephrolithiasis.

Abstract:

The murine homologue of the human chloride channel gene, CLCN5, defects in which are responsible for Dent disease, has been cloned and characterized. We isolated the entire coding region of mouse Clcn5 cDNA and approximately 45 kb of genomic sequence embracing the gene. To study its transcriptional control, the 5' upstream sequences of the mouse Clcn5 gene were cloned into a luciferase reporter vector. Deletion analysis of 1.5 kb of the 5' flanking sequence defined an active promoter region w...

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Publication status:
Published

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Publisher copy:
10.1006/geno.1999.5839

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Genomics
Volume:
58
Issue:
3
Pages:
281-292
Publication date:
1999-06-05
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
URN:
uuid:513b5b6d-6cb5-435d-835a-ea03a6d51a67
Source identifiers:
31510
Local pid:
pubs:31510

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