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Functional effects of the DCM mutant Gly159Asp troponin C in skinned muscle fibres.

Abstract:

We recently reported a dilated cardiomyopathy (DCM) causing mutation in a novel disease gene, TNNC1, which encodes cardiac troponin C (TnC). We have determined how this mutation, Gly159Asp, affects contractile regulation when incorporated into muscle fibres. Endogenous troponin in rabbit skinned psoas fibres was partially replaced by recombinant human cardiac troponin containing either wild-type or Gly159Asp TnC. We measured both the force-pCa relationship of these fibres and the activation r...

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Publication status:
Published

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Publisher copy:
10.1007/s00424-006-0161-7

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Journal:
Pflugers Archiv : European journal of physiology
Volume:
453
Issue:
6
Pages:
771-776
Publication date:
2007-03-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:5139b2e2-2dc0-4b6d-9aaa-315bd22b43bf
Source identifiers:
104228
Local pid:
pubs:104228

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