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Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria.

Abstract:

The continuing spread of multidrug resistance in Plasmodium falciparum malaria makes the search for alternative treatments ever more urgent. We have investigated the relative efficacy of halofantrine and mefloquine in two paired randomised trials on the Thai-Burmese border, a multidrug-resistant area. In the first trial, 198 patients with acute uncomplicated falciparum malaria were randomly assigned either the standard halofantrine regimen (24 mg/kg) or mefloquine (25 mg/kg). The cumulative f...

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Publication status:
Published

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Authors


ter Kuile, FO More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Edstein, MD More by this author
Luxemburger, C More by this author
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Journal:
Lancet (London, England)
Volume:
341
Issue:
8852
Pages:
1044-1049
Publication date:
1993-04-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:51392dcf-d588-4be6-be54-e8e64d242eb4
Source identifiers:
30909
Local pid:
pubs:30909

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