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Karyomapping: A single centre's experience from application of methodology to ongoing pregnancy and live-birth rates

Abstract:

This study aimed to determine whether karyomapping can be applied to couples requiring preimplantation genetic diagnosis (PGD) for single gene disorder (SGD) and/or chromosomal rearrangement. 75/82 (91.5%) and 6/82 (7.3%) couples were referred for autosomal SGD and X-linked disease, respectively. One couple (1.2%) was referred for SGD and chromosomal rearrangement. Of 608 embryos, 146 (24%, 95% CI 21–28) day-3 and 462 (76%, 95% CI 72–79) blastocyst biopsies were performed. A total of 81 embry...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.rbmo.2017.06.004

Authors


Ben-Nagi, J More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Loutradi, K More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Reproductive BioMedicine Online Journal website
Volume:
35
Issue:
3
Pages:
264-271
Publication date:
2017-06-15
Acceptance date:
2017-06-06
DOI:
EISSN:
1472-6491
ISSN:
1472-6483
Pubs id:
pubs:820167
URN:
uri:5132c215-a177-496e-abbd-8192e262e031
UUID:
uuid:5132c215-a177-496e-abbd-8192e262e031
Local pid:
pubs:820167

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