Defining the role of common variation in the genomic and biological architecture of adult human height.

Journal article

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for ...

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Authors: Wood, A; Esko, T; Yang, J; Vedantam, S; Pers, T

• Publication status: Published
• Journal: Nature genetics
• Volume: 46
• Issue: 11
• Pages: 1173-1186
• Publication date: 2014-11-01
• DOI: 10.1038/ng.3097
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Body Height; Oligonucleotide Array Sequence Analysis; Analysis of Variance; PAGEGE Consortium; Humans; European Continental Ancestry Group; Adult; Genome-Wide Association Study; Electronic Medical Records and Genomics (eMEMERGEGE) Consortium; LifeLines Cohort Study; MIGen Consortium; Genetic Variation; Polymorphism, Single Nucleotide; Genetics, Population