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Defining the role of common variation in the genomic and biological architecture of adult human height.

Abstract:

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.3097

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Journal:
Nature genetics
Volume:
46
Issue:
11
Pages:
1173-1186
Publication date:
2014-11-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:512ca56c-8f96-45ab-9e4a-0c1529d035f8
Source identifiers:
485989
Local pid:
pubs:485989

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