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Antibiotic susceptibility of clinical Burkholderia pseudomallei isolates in northeast Thailand during 2015-2018 and the genomic characterization of β-lactam-resistant isolates

Abstract:

Melioidosis is an often fatal infection in tropical regions caused by an environmental bacterium, Burkholderia pseudomallei. Current recommended melioidosis treatment requires intravenous β-lactam antibiotics such as ceftazidime (CAZ), meropenem (MEM), or amoxicillin-clavulanic acid (AMC) and oral trimethoprim-sulfamethoxazole. Emerging antibiotic resistance could lead to therapy failure and high mortality. We performed a prospective multicenter study in northeast Thailand from 2015 to 2018 t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.02230-20

Authors


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Name:
Wellcome Trust
Grant:
106698/Z/14/A milestone
106698/B/14/Z milestone
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
65
Issue:
5
Article number:
e02230-20
Publication date:
2021-04-19
Acceptance date:
2020-12-17
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
33593842
Language:
English
Keywords:
Pubs id:
1162563
Local pid:
pubs:1162563
Deposit date:
2021-04-27

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