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Massive turnover of functional sequence in human and other mammalian genomes.

Abstract:

Despite the availability of dozens of animal genome sequences, two key questions remain unanswered: First, what fraction of any species' genome confers biological function, and second, are apparent differences in organismal complexity reflected in an objective measure of genomic complexity? Here, we address both questions by applying, across the mammalian phylogeny, an evolutionary model that estimates the amount of functional DNA that is shared between two species' genomes. Our main findings...

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Publication status:
Published

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Publisher copy:
10.1101/gr.108795.110

Authors


Ponting, CP More by this author
Journal:
Genome research
Volume:
20
Issue:
10
Pages:
1335-1343
Publication date:
2010-10-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:512b3424-e1a5-4976-ac08-4979db344258
Source identifiers:
68120
Local pid:
pubs:68120

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