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Structure of the core of the type III secretion system export apparatus

Abstract:

Export of proteins through type III secretion systems is critical for motility and virulence of many major bacterial pathogens. Three putative integral membrane proteins (FliP, FliQ, FliR) are suggested to form the core of an export gate in the inner membrane, but their structure, assembly and location within the final nanomachine remain unclear. Here, we present the cryoelectron microscopy structure of the Salmonella Typhimurium FliP–FliQ–FliR complex at 4.2 Å. None of the subunits adopt can...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41594-018-0086-9

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0002-9554-3790
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0002-7877-3543
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
ORCID:
0000-0001-7686-2983
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
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Grant:
Investigator Award (100298)
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Grant:
programme grant (M011984)
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Grant:
Advanced Grant ENABLE (641317)
Alexander von Humboldt Foundation More from this funder
Deutsche Forschungsgemeinschaft More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Structural and Molecular Biology Journal website
Volume:
25
Pages:
583–590
Publication date:
2018-07-02
Acceptance date:
2018-06-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Pubs id:
pubs:865569
URN:
uri:50fc7095-e861-444c-9ef7-bab8a1409f73
UUID:
uuid:50fc7095-e861-444c-9ef7-bab8a1409f73
Local pid:
pubs:865569
Language:
English

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