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Journal article

The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.

Abstract:

The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in the post-transcriptional regulation of inflammatory genes. p38 has been found to regulate both the translation and the stability of inflammatory mRNAs. The mRNAs regulated by p38 share common AU-rich elements (ARE) present in their 3'-untranslated regions. AREs act as mRNA instability determinants but also confer stabilisation of the mRNA by the p38 pathway. In recent years, AREs have shown to be binding sites ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Cellular signalling
Volume:
16
Issue:
10
Pages:
1113-1121
Publication date:
2004-10-05
DOI:
EISSN:
1873-3913
ISSN:
0898-6568
URN:
uuid:50fa8e26-63ac-4cfd-bb96-eec6913dfcb9
Source identifiers:
224221
Local pid:
pubs:224221

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