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Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis.

Abstract:

The design and execution of prevention trials for OA have methodological issues that are distinct from trials designed to impact prevalent disease. Disease definitions and their precise and sensitive measurement, identification of high-risk populations, the nature of the intervention (pharmaceutical, nutraceutical, behavioral) and its potential pleiotropic impacts on other organ systems are critical to consider. Because prevention trials may be prolonged, close attention to concomitant life c...

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Publisher copy:
10.1016/j.joca.2010.10.031

Authors


Jordan, JM More by this author
Sowers, MF More by this author
Messier, SP More by this author
Bradley, J More by this author
Arangio, G More by this author
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Journal:
Osteoarthritis Cartilage
Volume:
19
Issue:
5
Pages:
500-508
Publication date:
2011-05-05
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:50f656f4-8832-40cc-9b99-4a93a3672c8c
Source identifiers:
126411
Local pid:
pubs:126411

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