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Collagenase does not persist in human islets following isolation.

Abstract:

Optimal human islet isolation requires the delivery of bacterial collagenase to the pancreatic islet-exocrine interface. However, we have previously demonstrated the presence of collagenase within human islets immediately following intraductal collagenase administration. This potentially has significant implications for patient safety. The present study aimed to determine if collagenase becomes internalized into islets during the isolation procedure and if it remains within the islet postisol...

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Publication status:
Published

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Publisher copy:
10.3727/096368912x636975

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Hughes, SJ More by this author
Johnson, PR More by this author
Journal:
Cell transplantation
Volume:
21
Issue:
11
Pages:
2531-2535
Publication date:
2012
DOI:
EISSN:
1555-3892
ISSN:
0963-6897
URN:
uuid:50de7c3a-9d25-4c78-8146-cfabe1625d51
Source identifiers:
371418
Local pid:
pubs:371418
Language:
English
Keywords:

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