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Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase.

Abstract:

A key stage during homologous recombination is the processing of the Holliday junction, which determines the outcome of the recombination reaction. To dissect the pathways of Holliday junction processing in a eukaryote, we have targeted an Escherichia coli Holliday junction resolvase to the nuclei of fission yeast recombination-deficient mutants and analysed their phenotypes. The resolvase partially complements the UV and hydroxyurea hypersensitivity and associated aberrant mitoses of an rqh1...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/19.11.2751

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
The EMBO journal
Volume:
19
Issue:
11
Pages:
2751-2762
Publication date:
2000-06-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:50de3abb-ca4a-4f28-9d3c-b0abc351a9f4
Source identifiers:
100016
Local pid:
pubs:100016

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