- Abstract:
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BACKGROUND: RTS,S/AS01(E) is the lead candidate pre-erythrocytic malaria vaccine. In Phase IIb field trials the safety profile was acceptable and the efficacy was 53% (95%CI 31%-72%) for protecting children against clinical malaria caused by P. falciparum. We studied CS-specific T cell responses in order to identify correlates of protection. METHODS AND FINDINGS: We used intracellular cytokine staining (for IL2, IFNγ, and TNFα), ex-vivo ELISPOTs (IFNγ and IL2) and IFNγ cultured ELISPOT assay...
Expand abstract - Publication status:
- Published
- Files:
-
-
(pdf, 496.3KB)
-
- Publisher copy:
- 10.1371/journal.pone.0025786
-
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- Journal:
- PloS one
- Volume:
- 6
- Issue:
- 10
- Pages:
- e25786
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- URN:
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uuid:50c1638d-601d-4b5c-ab29-6d9d3f9b86d0
- Source identifiers:
-
192943
- Local pid:
- pubs:192943
- Copyright date:
- 2011
Journal article
Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria.
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