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Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord.

Abstract:

Using immunocytochemistry and in situ hybridization, we have examined the expression of brain-derived neurotrophic factor (BDNF) and of neurotrophin receptors in dorsal root ganglion cells. In the adult rat, BDNF mRNA and protein were found mainly in the subpopulation of cells that express the nerve growth factor (NGF) receptor trkA and the neuropeptide calcitonin gene-related peptide (CGRP). NGF increased BDNF within the trkA/CGRP cells to the extent that almost 90% of trkA cells contained B...

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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
17
Issue:
21
Pages:
8476-8490
Publication date:
1997-11-05
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:50bd753f-8185-40e2-872a-7cd393607f57
Source identifiers:
365811
Local pid:
pubs:365811

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