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Reconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex

Abstract:

Competing accounts propose that working memory (WM) is subserved either by persistent activity in single neurons or by dynamic (time-varying) activity across a neural population. Here we compare these hypotheses across four regions of prefrontal cortex (PFC) in a spatial WM task, where an intervening distractor indicated the reward available for a correct saccade. WM representations were strongest in ventrolateral PFC (VLPFC) neurons with higher intrinsic temporal stability (time-constant). A...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-05873-3

Authors


Cavanagh, SE More by this author
Towers, JP More by this author
Wallis, JD More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Psychiatry
ORCID:
0000-0002-8393-8533
Kennerley, SW More by this author
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Funding agency for:
Hunt, LT
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Publication date:
2018-08-29
Acceptance date:
2018-07-31
DOI:
EISSN:
2041-1723
Pubs id:
pubs:896972
URN:
uri:50b9da77-b7a6-4e6d-8024-dca1a25fb03b
UUID:
uuid:50b9da77-b7a6-4e6d-8024-dca1a25fb03b
Local pid:
pubs:896972

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