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Journal article

Lysine methylation and the regulation of p53.

Abstract:

The p53 tumour suppressor protein functions as a guardian against genotoxic stress. This function is mediated in part by the transcriptional activation of genes involved in cell-cycle arrest, apoptosis, DNA repair and autophagy. The activity of p53 is regulated by a complex array of post-translational modifications, which function as a code to determine cellular responses to a given stress. In this chapter we highlight recent advances in our understanding of this code, with particular referen...

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Publication status:
Published

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Publisher copy:
10.1042/bse0520079

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Journal:
Essays in biochemistry
Volume:
52
Issue:
1
Pages:
79-92
Publication date:
2012-01-01
DOI:
EISSN:
1744-1358
ISSN:
0071-1365
URN:
uuid:50ab790d-9dec-4307-848b-0cc116d0ee20
Source identifiers:
339980
Local pid:
pubs:339980

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