Journal article icon

Journal article

Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal

Abstract:

Adaptive evolution in humans has rarely been characterized for its whole set of components, i.e. selective pressure, adaptive phenotype, beneficial alleles and realized fitness differential. We combined approaches for detecting polygenic adaptations and for mapping the genetic bases of physiological and fertility phenotypes in approximately 1000 indigenous ethnically Tibetan women from Nepal, adapted to high altitude. The results of genome-wide association analyses and tests for polygenic ada...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pgen.1007650

Authors


More by this author
Role:
Author
ORCID:
0000-0003-3049-2352
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0002-0947-489X
Expand authors...
National Science Foundation More from this funder
Dartmouth College More from this funder
University of Chicago More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
14
Issue:
9
Pages:
e1007650
Publication date:
2018-09-06
Acceptance date:
2018-08-21
DOI:
ISSN:
1553-7390 and 1553-7404
Pubs id:
pubs:915446
URN:
uri:509dd4e2-cf68-45ea-9f70-73802ba01bd2
UUID:
uuid:509dd4e2-cf68-45ea-9f70-73802ba01bd2
Local pid:
pubs:915446
Language:
English
Keywords:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP