- Abstract:
-
Adaptive evolution in humans has rarely been characterized for its whole set of components, i.e. selective pressure, adaptive phenotype, beneficial alleles and realized fitness differential. We combined approaches for detecting polygenic adaptations and for mapping the genetic bases of physiological and fertility phenotypes in approximately 1000 indigenous ethnically Tibetan women from Nepal, adapted to high altitude. The results of genome-wide association analyses and tests for polygenic ada...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.2MB)
-
- Publisher copy:
- 10.1371/journal.pgen.1007650
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 14
- Issue:
- 9
- Pages:
- e1007650
- Publication date:
- 2018-09-06
- Acceptance date:
- 2018-08-21
- DOI:
- ISSN:
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1553-7390 and 1553-7404
- Pubs id:
-
pubs:915446
- URN:
-
uri:509dd4e2-cf68-45ea-9f70-73802ba01bd2
- UUID:
-
uuid:509dd4e2-cf68-45ea-9f70-73802ba01bd2
- Local pid:
- pubs:915446
- Language:
- English
- Keywords:
- Copyright holder:
- Jeong et al
- Copyright date:
- 2018
- Notes:
- © 2018 Jeong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal
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National Science Foundation
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Dartmouth College
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University of Chicago
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