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Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal

Abstract:

Adaptive evolution in humans has rarely been characterized for its whole set of components, i.e. selective pressure, adaptive phenotype, beneficial alleles and realized fitness differential. We combined approaches for detecting polygenic adaptations and for mapping the genetic bases of physiological and fertility phenotypes in approximately 1000 indigenous ethnically Tibetan women from Nepal, adapted to high altitude. The results of genome-wide association analyses and tests for polygenic ada...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1007650

Authors


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Role:
Author
ORCID:
0000-0003-3049-2352
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Role:
Author
ORCID:
0000-0002-0947-489X
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National Science Foundation More from this funder
Dartmouth College More from this funder
University of Chicago More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
14
Issue:
9
Pages:
e1007650
Publication date:
2018-09-06
Acceptance date:
2018-08-21
DOI:
ISSN:
1553-7390 and 1553-7404
Pmid:
30188897
Source identifiers:
915446
Language:
English
Keywords:
Pubs id:
pubs:915446
UUID:
uuid:509dd4e2-cf68-45ea-9f70-73802ba01bd2
Local pid:
pubs:915446
Deposit date:
2018-11-20

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