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Neutrophil recruitment and articular hyperalgesia in antigen-induced arthritis are modulated by the cholinergic anti-inflammatory pathway

Abstract:

The cholinergic anti-inflammatory pathway (CAP) is a complex neuroimmune mechanism triggered by the central nervous system to regulate peripheral inflammatory responses. Understanding the role of CAP in the pathogenesis of rheumatoid arthritis (RA) could help develop new therapeutic strategies for this disease. Therefore, we investigated the participation of this neuroimmune pathway on the progression of experimental arthritis. Using antigen-induced arthritis (AIA) model, we investigated in m...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1111/bcpt.12611

Authors


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ORCID:
0000-0003-0367-7503
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
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ORCID:
0000-0002-3619-907X
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Publisher:
Wiley Publisher's website
Journal:
Basic and Clinical Pharmacology and Toxicology Journal website
Volume:
119
Issue:
5
Pages:
453-457
Publication date:
2016-04-21
Acceptance date:
2016-04-11
DOI:
EISSN:
1742-7843
ISSN:
1742-7835
Pubs id:
pubs:687573
URN:
uri:509a592e-7303-4dc6-b8c1-06bb930d5124
UUID:
uuid:509a592e-7303-4dc6-b8c1-06bb930d5124
Local pid:
pubs:687573

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