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"Giant surfactants" created by the fast and efficient functionalization of a DNA tetrahedron with a temperature-responsive polymer.

Abstract:

Copper catalyzed azide-alkyne cycloaddition (CuAAC) was employed to synthesize DNA block copolymers (DBCs) with a range of polymer blocks including temperature-responsive poly(N-isoproylacrylamide) (poly(NIPAM)) and highly hydrophobic poly(styrene). Exceptionally high yields were achieved at low DNA concentrations, in organic solvents, and in the absence of any solid support. The DNA segment of the DBC remained capable of sequence-specific hybridization: it was used to assemble a precisely de...

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Publication status:
Published

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Publisher copy:
10.1021/nn402642a

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Journal:
ACS nano
Volume:
7
Issue:
10
Pages:
8561-8572
Publication date:
2013-10-05
DOI:
EISSN:
1936-086X
ISSN:
1936-0851
URN:
uuid:5097e419-3c7f-4879-a805-eae2049ef40d
Source identifiers:
429109
Local pid:
pubs:429109

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