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Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with Influenza A virus

Abstract:

MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression, which have been shown to fine-tune innate immune responses downstream of pattern recognition receptor (PRR) signaling. This study identifies miR-650 as a novel PRR-responsive miRNA which is downregulated upon stimulation of primary human monocyte-derived dendritic cells (MDDCs) with a variety of different microbe-associated molecular patterns (MAMPs). A comprehensive target search combining in silico analysis...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/eji.201444970

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Pichulik, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Publisher:
Wiley-VCH Verlag Publisher's website
Journal:
European Journal of Immunology Journal website
Volume:
46
Issue:
1
Pages:
167–177
Publication date:
2016-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:508eda1c-35b3-4f74-b820-d8e5f7fd4592
Source identifiers:
571223
Local pid:
pubs:571223
Language:
English

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