Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with Influenza A virus
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression, which have been shown to fine-tune innate immune responses downstream of pattern recognition receptor (PRR) signaling. This study identifies miR-650 as a novel PRR-responsive miRNA which is downregulated upon stimulation of primary human monocyte-derived dendritic cells (MDDCs) with a variety of different microbe-associated molecular patterns (MAMPs). A comprehensive target search combining in silico analysis...Expand abstract
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- Pichulik et al.
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Copyright © 2015 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
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