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Evidence for the effectiveness and safety of immunologic therapies in women with subfertility: a systematic review and meta-analysis

Abstract:

Implantation is a critical step in the establishment of a successful pregnancy, depending on a complex immune-endocrine dialogue between the developing embryo and maternal endometrium. Research suggests that altered immunity in the maternal decidua results in implantation impairment and failure. Immunomodulatory drugs have, thus, been widely used in assisted conception to aid embryo implantation, despite an absence of consensus on their effectiveness and safety. We conducted a systematic revi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.fertnstert.2022.04.015

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Institution:
University of Oxford
Division:
MSD
Department:
Women's & Reproductive Health
Oxford college:
Pembroke College
Role:
Author
ORCID:
0000-0002-7056-5723
Publisher:
Elsevier
Journal:
Fertility and Sterility More from this journal
Volume:
117
Issue:
6
Pages:
1144-1159
Publication date:
2022-05-24
Acceptance date:
2022-04-12
DOI:
ISSN:
0015-0282
Language:
English
Keywords:
Pubs id:
1260763
Local pid:
pubs:1260763
Deposit date:
2022-05-24

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