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Clonality in the myelodysplastic syndromes.

Abstract:

The myelodysplastic syndromes (MDSs) comprise a heterogeneous group of stem cell disorders involving cytopenia and dysplastic changes in 3 hematopoietic lineages. Although it is accepted that MDS is a clonal disorder, the exact nature of the involvement of multipotent stem cells and progenitor cells has not been resolved. Most clonality studies of MDS support the proposal that the primary neoplastic event occurs, in most patients, at the level of a committed myeloid progenitor cell, capable o...

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Publication status:
Published

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Publisher copy:
10.1007/bf02994002

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Wainscoat, JS More by this author
Journal:
International journal of hematology
Volume:
73
Issue:
4
Pages:
411-415
Publication date:
2001-06-05
DOI:
EISSN:
1865-3774
ISSN:
0925-5710
URN:
uuid:50611b8d-48ef-427c-925d-82de44ef9ab0
Source identifiers:
246205
Local pid:
pubs:246205

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