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Immune recognition of HLA molecules downmodulates CD8 expression on cytotoxic T lymphocytes.

Abstract:

An HLA-A2+ cytotoxic T lymphocyte (CTL) line restricted by HLA-A2 in recognition of an influenza B virus nucleoprotein (BNP) peptide uses the CD8 coreceptor in the recognition of this viral peptide. Incubation of these CTL with BNP peptide in the absence of antigen-presenting cells downmodulates CD8 alpha and CD8 beta expression and reduces their ability to lyse target cells without inducing self-lysis. CD8 downmodulation was dependent on peptide concentration, time of exposure, and T cell re...

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Publication status:
Published

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Publisher copy:
10.1084/jem.173.1.221

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
The Journal of experimental medicine
Volume:
173
Issue:
1
Pages:
221-230
Publication date:
1991-01-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:504c92ff-9281-467a-a42d-d453d5d02be0
Source identifiers:
34470
Local pid:
pubs:34470

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