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Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction

Abstract:

Regulation of transient interactions between cells and the ubiquitous matrix glycosaminoglycan hyaluronan is crucial to such fundamental processes as embryonic development and leukocyte homing. Cd44, the primary cell surface receptor for hyaluronan, binds ligand via a lectin-like fold termed the Link module, but only after appropriate functional activation. The molecular details of the Cd44-hyaluronan interaction and hence the structural basis for this activation are unknown. Here we present ...

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Publisher copy:
10.1038/nsmb1201

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Nature Structural and Molecular Biology
Volume:
14
Issue:
3
Pages:
234-239
Publication date:
2007-03-05
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:5042e4bd-631e-4dc1-974b-99921a9385b1
Source identifiers:
102564
Local pid:
pubs:102564
Language:
English

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