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Asymptomatic children with multiple endocrine neoplasia type 1 mutations may harbor nonfunctioning pancreatic neuroendocrine tumors.

Abstract:

CONTEXT: Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of parathyroid, pituitary, and pancreatic tumors. MEN1, an autosomal dominant disorder, has a high degree of penetrance, such that more than 95% of patients develop clinical manifestations by the fifth decade, although this is lower at approximately 50% by age 20 yr. However, the lower penetrance in the younger group, which is based on detecting hormone-secreting tumors, may be an underestimate because pati...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2009-0564

Authors


Jeyabalan, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Christie, PT More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Biomedical Research Centre, Experimental Medicine Division
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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
94
Issue:
10
Pages:
3640-3646
Publication date:
2009-10-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:502d134d-c8aa-4f6d-bef9-22f5a1b4be20
Source identifiers:
34804
Local pid:
pubs:34804

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