- Abstract:
-
CONTEXT: Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of parathyroid, pituitary, and pancreatic tumors. MEN1, an autosomal dominant disorder, has a high degree of penetrance, such that more than 95% of patients develop clinical manifestations by the fifth decade, although this is lower at approximately 50% by age 20 yr. However, the lower penetrance in the younger group, which is based on detecting hormone-secreting tumors, may be an underestimate because pati...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1210/jc.2009-0564
-
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- Journal:
- The Journal of clinical endocrinology and metabolism
- Volume:
- 94
- Issue:
- 10
- Pages:
- 3640-3646
- Publication date:
- 2009-10-05
- DOI:
- EISSN:
-
1945-7197
- ISSN:
-
0021-972X
- URN:
-
uuid:502d134d-c8aa-4f6d-bef9-22f5a1b4be20
- Source identifiers:
-
34804
- Local pid:
- pubs:34804
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Asymptomatic children with multiple endocrine neoplasia type 1 mutations may harbor nonfunctioning pancreatic neuroendocrine tumors.
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