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Functional association between viral and cellular transcription during influenza virus infection.

Abstract:

Influenza viruses replicate and transcribe their segmented negative-sense single-stranded RNA genome in the nucleus of the infected host cell. All RNA synthesising activities associated with influenza virus are performed by the virally encoded RNA-dependent RNA polymerase (RdRp) that consists of three subunits, PA, PB1 and PB2. However, viral transcription is critically dependent on on-going cellular transcription, in particular, on activities associated with the cellular DNA-dependent RNA po...

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Publication status:
Published

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Publisher copy:
10.1002/rmv.512

Authors


Engelhardt, OG More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Reviews in medical virology
Volume:
16
Issue:
5
Pages:
329-345
Publication date:
2006
DOI:
EISSN:
1099-1654
ISSN:
1052-9276
URN:
uuid:502ce53e-444e-48ee-bd3a-905c8b8a9e2b
Source identifiers:
21341
Local pid:
pubs:21341

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