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Intrapartum single-dose carbamazepine reduces nevirapine levels faster and may decrease resistance after a single dose of nevirapine for perinatal HIV prevention.

Abstract:

BACKGROUND: World Health Organization guidelines recommend zidovudine + lamivudine for 7 days from labor onset in HIV-infected women receiving single-dose nevirapine (sdNVP) to cover prolonged subtherapeutic nevirapine concentrations. Although effective, this is complicated and does not eliminate resistance; alternative strategies could add benefit. METHODS: Antiretroviral-naive HIV-infected pregnant women aged 18-40 years, with CD4 >200 cells per cubic millimeter, able to regularly attend...

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Publication status:
Published

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Authors


Fillekes, Q More by this author
Kisanga, ER More by this author
L'homme, R More by this author
Aitken, SC More by this author
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Journal:
Journal of acquired immune deficiency syndromes (1999)
Volume:
59
Issue:
3
Pages:
266-273
Publication date:
2012-03-05
DOI:
EISSN:
1944-7884
ISSN:
1525-4135
URN:
uuid:502bbaf0-ddc8-4c1e-82ca-fd19c5040864
Source identifiers:
422907
Local pid:
pubs:422907

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