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Elucidating in vitro and in vivo phenotypic behaviour of L. infantum/L. major natural hybrids

Abstract:

The clinical manifestation and course of Leishmania infections depend on factors such as species, virulence and host-immunity. Although trypanosomatids are considered to have clonal propagation, genetic hybridization has produced successful natural hybrid lineages. Hybrids displaying strong selective advantages may have an impact on pathogenesis and the eco-epidemiology of leishmaniasis. Thus, characterization of phenotypic properties of Leishmania hybrids could bring significant insight into...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1017/s0031182018001993

Authors


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ORCID:
0000-0001-5850-6950
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Carvalho, M More by this author
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Publisher:
Cambridge University Press Publisher's website
Journal:
Parasitology Journal website
Volume:
146
Issue:
5
Pages:
580-587
Publication date:
2018-11-29
Acceptance date:
2018-10-28
DOI:
EISSN:
1469-8161
ISSN:
0031-1820
Pubs id:
pubs:972978
URN:
uri:50255b1f-a69f-4dd3-a706-a8f6d65cde70
UUID:
uuid:50255b1f-a69f-4dd3-a706-a8f6d65cde70
Local pid:
pubs:972978

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