- Abstract:
-
Genome-wide association studies have identified SNPs within FTO, the human fat mass and obesity-associated gene, that are strongly associated with obesity. Individuals homozygous for the at-risk rs9939609 A allele weigh, on average, ~3 kg more than individuals with the low-risk T allele. Mice that lack FTO function and/or Fto expression display increased energy expenditure and a lean phenotype. We show here that ubiquitous overexpression of Fto leads to a dose-dependent increase in body and f...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ng.713
-
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- Journal:
- Nature genetics
- Volume:
- 42
- Issue:
- 12
- Pages:
- 1086-1092
- Publication date:
- 2010-12-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:5020baf4-e1d2-4eb6-a9b0-72f693662ed3
- Source identifiers:
-
114802
- Local pid:
- pubs:114802
- Copyright date:
- 2010
Journal article
Overexpression of Fto leads to increased food intake and results in obesity.
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