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Journal article

Overexpression of Fto leads to increased food intake and results in obesity.

Abstract:

Genome-wide association studies have identified SNPs within FTO, the human fat mass and obesity-associated gene, that are strongly associated with obesity. Individuals homozygous for the at-risk rs9939609 A allele weigh, on average, ~3 kg more than individuals with the low-risk T allele. Mice that lack FTO function and/or Fto expression display increased energy expenditure and a lean phenotype. We show here that ubiquitous overexpression of Fto leads to a dose-dependent increase in body and f...

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Publication status:
Published

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Publisher copy:
10.1038/ng.713

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Journal:
Nature genetics
Volume:
42
Issue:
12
Pages:
1086-1092
Publication date:
2010-12-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:5020baf4-e1d2-4eb6-a9b0-72f693662ed3
Source identifiers:
114802
Local pid:
pubs:114802

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