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Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut.

Abstract:

We studied the transmission-blocking effect of isonicotinic acid hydrazide (INH), a widely used anti-tuberculosis drug, against Plasmodium gallinaceum and Plasmodium berghei. INH-treatment of infected animals did not inhibit parasite development in the blood of the vertebrate host, but did inhibit exflagellation, ookinete formation, and oocyst development in the mosquito. Oocyst development was inhibited in a dose-dependent manner. The ED(50) in the P. gallinaceum/chicken/Aedes aegypti model ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
Journal:
Experimental parasitology
Volume:
106
Issue:
1-2
Pages:
30-36
Publication date:
2004-01-01
DOI:
EISSN:
1090-2449
ISSN:
0014-4894
URN:
uuid:5010bcd3-b549-4cc4-8ad5-b36363d06842
Source identifiers:
260455
Local pid:
pubs:260455

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