Journal article
Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells
- Abstract:
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Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a notable cause of cancer mortality when it metastasises. The unfolded protein response (UPR) can be cytoprotective but when acutely activated can lead to cell death. In this study, we sought to enhance the acute activation of the UPR using radiation and ONC201, an UPR activator. Treating PCa cells with ONC201 quickly increased the expression of all the key regulators of the UPR and reduced the oxidative phosphorylation,...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.6MB, Terms of use)
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- Publisher copy:
- 10.1038/s41598-021-83215-y
Authors
Bibliographic Details
- Publisher:
- Nature Research
- Journal:
- Scientific Reports More from this journal
- Volume:
- 11
- Issue:
- 1
- Article number:
- 4252
- Publication date:
- 2021-02-19
- Acceptance date:
- 2021-02-01
- DOI:
- EISSN:
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2045-2322
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1163119
- Local pid:
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pubs:1163119
- Deposit date:
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2021-02-23
Terms of use
- Copyright holder:
- Amoroso et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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