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Motogenic sites in human fibronectin are masked by long range interactions.

Abstract:

Fibronectin (FN) is a large extracellular matrix glycoprotein important for development and wound healing in vertebrates. Recent work has focused on the ability of FN fragments and embryonic or tumorigenic splicing variants to stimulate fibroblast migration into collagen gels. This activity has been localized to specific sites and is not exhibited by full-length FN. Here we show that an N-terminal FN fragment, spanning the migration stimulation sites and including the first three type III FN ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m109.003673

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Staunton, D More by this author
Sarkies, P More by this author
Flanagan, A More by this author
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Journal:
The Journal of biological chemistry
Volume:
284
Issue:
23
Pages:
15668-15675
Publication date:
2009-06-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:4fff0526-4a32-4aef-b7e3-8400d269a6b1
Source identifiers:
196802
Local pid:
pubs:196802

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