Journal article icon

Journal article

Steroid-induced deficiency of mucosal-associated invariant T cells in the chronic obstructive pulmonary disease lung. Implications for nontypeable haemophilus influenzae infection

Abstract:

RATIONALE: Mucosal-associated invariant T (MAIT) cells are a recently described abundant, proinflammatory T-cell subset with unknown roles in pulmonary immunity. Nontypeable Haemophilus influenzae (NTHi) is the leading bacterial pathogen during chronic obstructive pulmonary disease (COPD) exacerbations and is a plausible target for MAIT cells. OBJECTIVES: To investigate whether MAIT cells respond to NTHi and the effects of inhaled corticosteroids (ICS) on their frequency and function in COPD....

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1164/rccm.201601-0002OC

Authors


More by this author
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Wallington, JC More by this author
Williams, AP More by this author
Djukanović, R More by this author
Staples, KJ More by this author
Expand authors...
More from this funder
Funding agency for:
Hinks, TS
Publisher:
American Thoracic Society Publisher's website
Journal:
American Journal of Respiratory and Critical Care Medicine Journal website
Volume:
194
Issue:
10
Pages:
1208-1218
Publication date:
2016-11-15
Acceptance date:
2016-04-25
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
Pubs id:
pubs:705497
URN:
uri:4fe613e7-112a-4e95-876c-14471fcce4cf
UUID:
uuid:4fe613e7-112a-4e95-876c-14471fcce4cf
Local pid:
pubs:705497
Paper number:
10
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP