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Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome.

Abstract:

Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is a predictor of mortality in critical illness. Severe malaria (SM) is associated with decreased NO bioavailability, but the contribution of ADMA to the pathogenesis of impaired NO bioavailability and adverse outcomes in malaria is unknown. In adults with and without falciparum malaria, we tested the hypotheses that plasma ADMA would be: 1) increased in proportion to disease severity, 2) associated ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1000868

Authors


Lampah, DA More by this author
Gitawati, R More by this author
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Funding agency for:
Price, RN
Veterans Affairs Research Service More from this funder
Tudor Foundation More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
6
Issue:
4
Pages:
e1000868
Publication date:
2010-04-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:4fda972d-0154-4d53-953c-431650841efb
Source identifiers:
61483
Local pid:
pubs:61483

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