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Benefits and harms in pivotal trials of oral centrally acting antiobesity medicines: A systematic review and meta-analysis.

Abstract:

Objectives

To evaluate the benefits and harms of oral centrally acting antiobesity medicinal products in pivotal trials.

Methods

The European Medicines Agency and Federal Drug Administration websites, PubMed, and ClinicalTrials. gov were searched to identify pivotal trials used to gain marketing authorizations. Pivotal phase III trials on which marketing authorizations were based were included. The data were analyzed by using Cochrane Review Manager (RevMan), and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/oby.22118

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
ORCID:
0000-0002-2420-0811
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
ORCID:
0000-0001-7883-4484
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Oxford college:
Kellogg College
University of Oxford More from this funder
National Institute for Health Research More from this funder
Publisher:
Wiley Publisher's website
Journal:
Obesity Journal website
Volume:
26
Issue:
3
Pages:
513–521
Publication date:
2018-02-05
Acceptance date:
2017-12-07
DOI:
EISSN:
1930-739X
ISSN:
1930-7381
Pubs id:
pubs:823337
URN:
uri:4fc64a21-13d2-4213-bffa-87920aab487e
UUID:
uuid:4fc64a21-13d2-4213-bffa-87920aab487e
Local pid:
pubs:823337
Language:
English
Keywords:
Subjects:

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