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Parkinson's disease, Alzheimer's disease and motor neurone disease: identifying a common mechanism.

Abstract:

Although Alzheimer's disease, Parkinson's disease, and motor neurone disease are distinct disorders, there could be a common neurodegenerative mechanism that characterises the death of selective neurone populations in each case. We propose that this mechanism could be an aberrantly activated, developmental process involving a non-classical, non-enzymatic action of acetylcholinesterase mediated via a short linear motif near the C-terminal end of the molecule. Since this motif has a highly cons...

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Publication status:
Published

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Authors


Greenfield, S More by this author
Journal:
Neuroscience
Volume:
113
Issue:
3
Pages:
485-492
Publication date:
2002
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
URN:
uuid:4fbd771b-de17-4f5b-b442-69e0b6f624da
Source identifiers:
16316
Local pid:
pubs:16316

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