Randomized clinical trials provide the most reliable estimates of the benefits and harms of treatments. Limited sample sizes restrict their power to allow informative analyses of secondary outcomes, or patient subgroups. The overall results of trials only apply to the average patient and clinical application ignores the individual patient differences.Meta-analysis in the context of a systematic review can produce more precise estimates of effect by combining the results of primary studies. Th...Expand abstract
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Meta-analysis in the assessment of treatment outcome.
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