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Opioids depress cortical centers responsible for the volitional control of respiration.

Abstract:

Respiratory depression limits provision of safe opioid analgesia and is the main cause of death in drug addicts. Although opioids are known to inhibit brainstem respiratory activity, their effects on cortical areas that mediate respiration are less well understood. Here, functional magnetic resonance imaging was used to examine how brainstem and cortical activity related to a short breath hold is modulated by the opioid remifentanil. We hypothesized that remifentanil would differentially depr...

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Publication status:
Published

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Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
29
Issue:
25
Pages:
8177-8186
Publication date:
2009-06-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Source identifiers:
241028

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