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Journal article

Opioids depress cortical centers responsible for the volitional control of respiration.

Abstract:

Respiratory depression limits provision of safe opioid analgesia and is the main cause of death in drug addicts. Although opioids are known to inhibit brainstem respiratory activity, their effects on cortical areas that mediate respiration are less well understood. Here, functional magnetic resonance imaging was used to examine how brainstem and cortical activity related to a short breath hold is modulated by the opioid remifentanil. We hypothesized that remifentanil would differentially depr...

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Publication status:
Published

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Authors


Pattinson, KT More by this author
Governo, RJ More by this author
MacIntosh, BJ More by this author
Russell, EC More by this author
Corfield, DR More by this author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
29
Issue:
25
Pages:
8177-8186
Publication date:
2009-06-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:4fbb15a0-dca3-4c67-a33d-2be90775f930
Source identifiers:
241028
Local pid:
pubs:241028

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