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Journal article

Challenges in design and interpretation of chronic pain trials.

Abstract:

The process of systematic review has shone a light on the methodology of randomized controlled trials. Notably, a range of potential biases hinders the interpretation of chronic pain trials. These include a consistent bias favouring active over placebo in trials that are small and of short duration. The use of the 'last observation carried forward' imputation method is known to inflate results, often generating statistically significance when adverse event withdrawals are high; in clinical pr...

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Publication status:
Published

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Publisher copy:
10.1093/bja/aet126

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
British journal of anaesthesia
Volume:
111
Issue:
1
Pages:
38-45
Publication date:
2013-07-01
DOI:
EISSN:
1471-6771
ISSN:
0007-0912
Source identifiers:
410902
Language:
English
Keywords:
Pubs id:
pubs:410902
UUID:
uuid:4fb62eb0-8126-42dd-b65a-f89fa0087545
Local pid:
pubs:410902
Deposit date:
2013-11-16

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