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Journal article

Challenges in design and interpretation of chronic pain trials.

Abstract:

The process of systematic review has shone a light on the methodology of randomized controlled trials. Notably, a range of potential biases hinders the interpretation of chronic pain trials. These include a consistent bias favouring active over placebo in trials that are small and of short duration. The use of the 'last observation carried forward' imputation method is known to inflate results, often generating statistically significance when adverse event withdrawals are high; in clinical pr...

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Publication status:
Published

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Publisher copy:
10.1093/bja/aet126

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
British journal of anaesthesia
Volume:
111
Issue:
1
Pages:
38-45
Publication date:
2013-07-05
DOI:
EISSN:
1471-6771
ISSN:
0007-0912
URN:
uuid:4fb62eb0-8126-42dd-b65a-f89fa0087545
Source identifiers:
410902
Local pid:
pubs:410902

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