Journal article
Challenges in design and interpretation of chronic pain trials.
- Abstract:
-
The process of systematic review has shone a light on the methodology of randomized controlled trials. Notably, a range of potential biases hinders the interpretation of chronic pain trials. These include a consistent bias favouring active over placebo in trials that are small and of short duration. The use of the 'last observation carried forward' imputation method is known to inflate results, often generating statistically significance when adverse event withdrawals are high; in clinical pr...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/bja/aet126
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Authors
Bibliographic Details
- Journal:
- British journal of anaesthesia
- Volume:
- 111
- Issue:
- 1
- Pages:
- 38-45
- Publication date:
- 2013-07-01
- DOI:
- EISSN:
-
1471-6771
- ISSN:
-
0007-0912
- Source identifiers:
-
410902
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:410902
- UUID:
-
uuid:4fb62eb0-8126-42dd-b65a-f89fa0087545
- Local pid:
- pubs:410902
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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