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Journal article

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.

Abstract:

Timely elimination of damaged mitochondria is essential to protect cells from the potential harm of disordered mitochondrial metabolism and release of proapoptotic proteins. In mammalian red blood cells, the expulsion of the nucleus followed by the removal of other organelles, such as mitochondria, are necessary differentiation steps. Mitochondrial sequestration by autophagosomes, followed by delivery to the lysosomal compartment for degradation (mitophagy), is a major mechanism of mitochondr...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0913170107

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
2
Pages:
832-837
Publication date:
2010-01-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:4fb2f4d2-4a6e-480f-b4b6-876ed8fefbb6
Source identifiers:
46153
Local pid:
pubs:46153

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