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Current trends in α-helical membrane protein crystallization: an update.

Abstract:

α-Helical membrane proteins (MPs) are the targets for many pharmaceutical drugs and play important roles in human physiology. In recent years, significant progress has been made in determining their atomic structure using X-ray crystallography. However, a major bottleneck in MP crystallography still remains, namely, the identification of conditions that give crystals that are suitable for structural determination. In 2008, we undertook an analysis of the crystallization conditions for 121 α-h...

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Publication status:
Published

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Publisher copy:
10.1002/pro.2122

Authors


Parker, JL More by this author
Newstead, S More by this author
Journal:
Protein science : a publication of the Protein Society
Volume:
21
Issue:
9
Pages:
1358-1365
Publication date:
2012-09-05
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
URN:
uuid:4fa7e518-af30-493e-9a19-cbc79c49bf8a
Source identifiers:
342322
Local pid:
pubs:342322

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