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A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines.

Abstract:

Early clinical investigations of candidate malaria vaccines and antimalarial medications increasingly employ an established model of controlled human malaria infection (CHMI). Study results are used to guide further clinical development of vaccines and antimalarial medications as CHMI results to date are generally predictive of efficacy in malaria-endemic areas. The urgency to rapidly develop an efficacious malaria vaccine has increased demand for efficacy studies that include CHMI and the ne...

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Authors


Laurens, MB More by this author
Duncan, CJ More by this author
Epstein, JE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Komisar, JL More by this author
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Journal:
Vaccine
Volume:
30
Issue:
36
Pages:
5302-5304
Publication date:
2012-08-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:4f9f9cb9-1df4-49f3-81bb-78735b5b86d7
Source identifiers:
344548
Local pid:
pubs:344548

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