- Abstract:
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BACKGROUND: In comparison to the classical isoforms of protein kinase C (PKC), the novel isoforms are thought to play minor or inhibitory roles in the regulation of platelet activation and thrombosis. OBJECTIVES: To measure the levels of PKCθ and PKCε and to investigate the phenotype of mice deficient in both novel PKC isoforms. METHODS: Tail bleeding and platelet activation assays were monitored in mice and platelets from mice deficient in both PKCθ and PKCε. RESULTS: PKCε plays a minor role...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1538-7836.2012.04857.x
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- Journal:
- Journal of thrombosis and haemostasis : JTH
- Volume:
- 10
- Issue:
- 9
- Pages:
- 1887-1894
- Publication date:
- 2012-09-05
- DOI:
- EISSN:
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1538-7836
- ISSN:
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1538-7933
- URN:
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uuid:4f9e278d-7b5f-418c-b4f4-4bff8921c9b1
- Source identifiers:
-
344174
- Local pid:
- pubs:344174
- Copyright date:
- 2012
Journal article
Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.
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