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Journal article

Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.

Abstract:

BACKGROUND: In comparison to the classical isoforms of protein kinase C (PKC), the novel isoforms are thought to play minor or inhibitory roles in the regulation of platelet activation and thrombosis. OBJECTIVES: To measure the levels of PKCθ and PKCε and to investigate the phenotype of mice deficient in both novel PKC isoforms. METHODS: Tail bleeding and platelet activation assays were monitored in mice and platelets from mice deficient in both PKCθ and PKCε. RESULTS: PKCε plays a minor role...

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Publication status:
Published

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Journal:
Journal of thrombosis and haemostasis : JTH
Volume:
10
Issue:
9
Pages:
1887-1894
Publication date:
2012-09-05
DOI:
EISSN:
1538-7836
ISSN:
1538-7933
URN:
uuid:4f9e278d-7b5f-418c-b4f4-4bff8921c9b1
Source identifiers:
344174
Local pid:
pubs:344174

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