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Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells.

Abstract:

Airway ciliary beat frequency regulation is complex but in part influenced by cyclic adenosine monophosphate (cAMP)-mediated changes in cAMP-dependent kinase activity, yet the cAMP concentration required for increases in ciliary beat frequency and the temporal relationship between ciliary beat frequency and cAMP changes are unknown. A lentiviral gene transfer system was developed to express a fluorescence resonance energy transfer (FRET)-based cAMP sensor in ciliated cells. Expression of fluo...

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Publisher copy:
10.1242/jcs.03181

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
Journal of cell science
Volume:
119
Issue:
Pt 20
Pages:
4176-4186
Publication date:
2006-10-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:4f9965e0-3682-4141-8e69-418963835b23
Source identifiers:
237842
Local pid:
pubs:237842

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