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Journal article

Identification of epigenetic DNA modifications with a protein nanopore.

Abstract:
Two DNA bases, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (hmC), marks of epigenetic modification, are recognized in immobilized DNA strands and distinguished from G, A, T and C by nanopore current recording. Therefore, if further aspects of nanopore sequencing can be addressed, the approach will provide a means to locate epigenetic modifications in unamplified genomic DNA.
Publication status:
Published

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Publisher copy:
10.1039/c0cc02864a

Authors


Wallace, EV More by this author
Stoddart, D More by this author
Mikhailova, E More by this author
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Journal:
Chemical communications (Cambridge, England)
Volume:
46
Issue:
43
Pages:
8195-8197
Publication date:
2010-11-05
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
URN:
uuid:4f82bcd9-9750-4842-a9bd-f2785c3ffc49
Source identifiers:
90277
Local pid:
pubs:90277

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