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Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories.

Abstract:

The idea that an NMDA receptor (NMDAR)-dependent long-term potentiation-like process in the hippocampus is the neural substrate for associative spatial learning and memory has proved to be extremely popular and influential. However, we recently reported that mice lacking NMDARs in dentate gyrus and CA1 hippocampal subfields (GluN1(ΔDGCA1) mice) acquired the open field, spatial reference memory watermaze task as well as controls, a result that directly challenges this view. Here, we show that ...

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Publication status:
Published

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Publisher copy:
10.1098/rstb.2013.0149

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
369
Issue:
1633
Pages:
20130149
Publication date:
2014-01-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:4f7c662e-1566-411b-9a03-0327f49aade6
Source identifiers:
441338
Local pid:
pubs:441338

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