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Journal article

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy

Abstract:

Activation of invariant CD1d-dependent NKT cells (iNKT cells) in vivo through administration of the glycolipid ligand α-galactosylceramide (α-GalCer) or the sphingosine-truncated α-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and γ interferons that contribute to DC maturation. This process enhances T cell immunity to antigens presented by the DC. The adjuvant activity is further amplified if APCs are stimulated through Toll-like recept...

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Publication status:
Published

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Publisher copy:
10.1172/JCI200422046

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Journal:
JOURNAL OF CLINICAL INVESTIGATION
Volume:
114
Issue:
12
Pages:
1800-1811
Publication date:
2004-12-01
DOI:
ISSN:
0021-9738
Source identifiers:
39296
Language:
English
Pubs id:
pubs:39296
UUID:
uuid:4f7b4b86-6f8c-4012-b892-991496eab57b
Local pid:
pubs:39296
Deposit date:
2012-12-19

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