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Pre-hospital assessment of the role of adrenaline: Measuring the effectiveness of drug administration in cardiac arrest (PARAMEDIC-2): Trial protocol

Abstract:

Despite its use since the 1960s, the safety or effectiveness of adrenaline as a treatment for cardiac arrest has never been comprehensively evaluated in a clinical trial. Although most studies have found that adrenaline increases the chance of return of spontaneous circulation for short periods, many studies found harmful effects on the brain and raise concern that adrenaline may reduce overall survival and/or good neurological outcome. The PARAMEDIC-2 trial seeks to determine if adrenaline i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Authors


Perkins, GD More by this author
Deakin, CD More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Resuscitation Journal website
Volume:
108
Pages:
75-81
Publication date:
2016-09-17
Acceptance date:
2016-08-26
DOI:
EISSN:
1873-1570
ISSN:
0300-9572
Pubs id:
pubs:648053
URN:
uri:4f7b3d6c-328d-4ce9-90de-7bf5d39c4437
UUID:
uuid:4f7b3d6c-328d-4ce9-90de-7bf5d39c4437
Local pid:
pubs:648053

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