Journal article icon

Journal article

Heat shock protein B1-deficient mice display impaired wound healing

Abstract:

There is large literature describing in vitro experiments on heat shock protein (hsp)B1 but understanding of its function in vivo is limited to studies in mice overexpressing human hspB1 protein. Experiments in cells have shown that hspB1 has chaperone activity, a cytoprotective role, regulates inflammatory gene expression, and drives cell proliferation. To investigate the function of the protein in vivo we generated hspB1-deficient mice. HspB1-deficient fibroblasts display increased expressi...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0077383

Authors


Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
8
Issue:
10
Pages:
ARTN e77383
Publication date:
2013-10-15
Acceptance date:
2013-09-05
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
435571
Language:
English
Keywords:
UUID:
uuid:4f78ea82-ac21-44d4-bed7-fcf44ded2938
Local pid:
pubs:435571
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP