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Journal article

Induction of tolerance in peripheral T cells with monoclonal antibodies.

Abstract:

Our goal has been to develop ways to tolerize the mature immune system to any defined antigen. In this report we show that peripheral (post-thymic) T cells of mice can become tolerant to a range of antigens (human and rat immunoglobulins, and bone marrow and skin grafts that differ at multiple minor transplantation antigens). In the case of human gamma globulin (HGG), this required that the antigen be given under the cover of a short course of non-depleting anti-CD4 antibody, while for tolera...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830201231

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
European journal of immunology
Volume:
20
Issue:
12
Pages:
2737-2745
Publication date:
1990-12-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:4f5e5abe-04f0-4eb8-b5e1-7fb95261ac10
Source identifiers:
3065
Local pid:
pubs:3065

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